Why ENiMoN?
Pain is subjective. Nociception begins under anesthesia.
During general anesthesia, patients cannot communicate pain directly. Intraoperative analgesic requirements are therefore often estimated using standardised workflows and indirect physiological responses such as heart rate or blood pressure — even though stress and pain responses are highly individual.
This creates a central challenge: both insufficient analgesia and unnecessary opioid administration may influence the perioperative course. Heart rate and blood pressure only partly reflect individual nociceptive load and stress response.
Novel nociception-monitoring approaches provide additional information about physiological responses to surgical stimulation. ENiMoN investigates how this information can be interpreted in the context of EEG, density spectral array, haemodynamics, therapeutic decisions, and other physiological signals.
The key is not a single measurement, but the entire physiological context — and the linking of intraoperative signal trajectories with postoperative outcomes.
What do we want to understand?
Nociception & Analgesia
Which physiological signals best describe individual nociceptive load — and how are measured nociception, surgical stimulation, and intraoperative analgesic therapy related?
Multimodal Physiology
What additional information emerges when nociception is analyzed together with EEG/DSA, haemodynamics and other physiological signals — and how do patients differ in their intraoperative stress response?
Intraoperative Therapy
How do different analgesic strategies affect opioid requirements, hemodynamic responses, vasopressor requirement, and other intraoperative treatment decisions?
Postoperative Outcomes
How are intraoperative nociception and analgesia associated with postoperative pain, opioid consumption, PONV, delirium, neurocognitive recovery, and other clinical outcomes?